Handayani, Dian, Edrada, Ru Angelie, Proksch, Peter, Wray, Victor, Witte, Ludger, Van Soest, Rob W. M., Kunzmann, Andreas ORCID: https://orcid.org/0000-0002-9500-4332 and Soedarsono, (1997) Four New Bioactive Polybrominated Diphenyl Ethers of the SpongeDysidea herbaceafrom West Sumatra, Indonesia. Journal of Natural Products, 60 (12). pp. 1313-1316. DOI https://doi.org/10.1021/np970271w.

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Abstract

The marine sponge Dysidea herbacea collected from Indonesia yielded four new polybrominated diphenyl ether congeners 2−5 and the known derivatives 1, 6, and 7. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct and long-range 13C− 1H correlations) and mass spectrometric (EIMS) data. All of the compounds were active against the Gram-positive bacteria Bacillus subtilis and the phytopathogenic fungus Cladosporium cucumerinum. The isolated polybrominated compounds were also active in the brine shrimp lethality test. In the latter bioassay, compounds 1 and 6 were the most active with LC50's of 0.96 [SE ± 0.19] and 0.94 [SE ± 0.70] μg/mL, respectively.

Document Type:	Article
Programme Area:	PA1
Research affiliation:	Ecology > Experimental Aquaculture
Refereed:	Yes
Open Access Journal?:	No
DOI:	https://doi.org/10.1021/np970271w
ISSN:	0163-3864
Date Deposited:	26 Feb 2026 13:47
Last Modified:	26 Feb 2026 13:47
URI:	https://cris.leibniz-zmt.de/id/eprint/6112

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