Luyen, Nguyen Dinh, Huong, Le Mai, Thi Hong Ha, Tran, Cuong, Le Huu, Thi Hai Yen, Duong, Nhiem, Nguyen Xuan, Tai, Bui Huu, Gärdes, Astrid, Kopprio, German and Van Kiem, Phan (2019) Aspermicrones A-C, novel dibenzospiroketals from the seaweed-derived endophytic fungus Aspergillus micronesiensis. The Journal of Antibiotics, 72 (11). pp. 843-847. DOI https://doi.org/10.1038/s41429-019-0214-8.

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Abstract

Chemical investigation of the Kappaphycus alvarezii-derived endophytic fungus Aspergillus micronesiensis lead to the isolation of three novel dibenzospiroketals, aspermicrones A-C (1-3). Their chemical structures were determined by extensive analysis of HR-ESI-MS and NMR spectral data. The absolute configurations of them were determined by experimental and TD-DFT theoretical calculated circular dichroism spectra. Compound 2 exhibited selective cytotoxic effect toward HepG2 cell line (IC50 = 9.9 µM). Additionally, both of compounds 2 and 3 displayed anti-microbial activity against Staphylococcus aureus (MIC = 123.2 µM for each compound). Compound 1 was inactivity in both cytotoxic and anti-microbial assays.

Document Type:	Article
Programme Area:	UNSPECIFIED
Research affiliation:	Biogeochemistry and Geology > Tropical Marine Microbiology
Refereed:	Yes
Open Access Journal?:	No
DOI:	https://doi.org/10.1038/s41429-019-0214-8
ISSN:	0021-8820
Date Deposited:	02 Dec 2019 12:41
Last Modified:	26 Mar 2024 13:30
URI:	http://cris.leibniz-zmt.de/id/eprint/3126

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